anorexia, anorexigenesis, Pickwickian, Obesity,hypoventilation/somnolentlence/bulimia

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WASHINGTONPOST.COM

anorexia (loss of appetite)



"The problem in obesity is not excess weight," Lustig says, in the central London hotel that he has made his anti-metabolic illness HQ. "The problem with obesity is that the brain is not seeing the excess weight." The brain can't see it because appetite is determined by a binary system. You're either in anorexigenesis – "I'm not hungry and I can burn energy" – or you're in orexigenesis – "I'm hungry and I want to store energy." The flip switch is your leptin level (the hormone that regulates your body fat) but too much insulin in your system blocks the leptin signal.


Obesity hypoventilation syndrome (also known as Pickwickian syndrome) is a condition in which severely overweight people fail to breathe rapidly enough or deeply enough, resulting in low blood oxygen levels and high blood carbon dioxide (CO₂) levels. Many people with this condition also frequently stop breathing altogether for short periods of time during sleep (obstructive sleep apnea), resulting in many partial awakenings during the night, which leads to continual sleepiness during the day.^[1] The disease puts strain on the heart, which eventually may lead to the symptoms of heart failure, such as leg swelling and various other related symptoms. The most effective treatment is weight loss, but it is often possible to relieve the symptoms by nocturnal ventilation with positive airway pressure (CPAP) or related methods.^[1][2]
Obesity hypoventilation syndrome is defined as the combination of obesity (body mass index above 30 kg/m²), hypoxia (falling oxygen levels in blood) during sleep, and hypercapnia (increased blood carbon dioxide levels) during the day, resulting from hypoventilation (excessively slow or shallow breathing).^[2][3] The disease has been known since the 1950s, initially as "Pickwickian syndrome" in reference to a Dickensian character but currently under a more descriptive name.^[2]

hypo-[hy・po-]

• 発音記号[háipou-, -pə-]

「下」「下方」；「より少ない」「従属した」；《化学》「次亜」（⇔hyper-）.

hỳperventilátion[hỳper・ventilátion] [名]《医学》過度呼吸；過呼吸症侯群.
somnolentlence[som・no・lentlence]

[名][U]眠いこと, 眠け.

bulimia名][U]

1 過食.

2 多食［過食］症(bulimia nervosa). ⇒ANOREXIA

anorexia (loss of appetite) 食欲不振

Anorexigenic: Causing anorexia (loss of appetite) as, for example, an anorexigenic drug.